The Four Noble Truths, phrased in a rather beautiful way
Then there are the four noble truths. In summary they are an observation that there is a great sadness in our human condition. That sadness comes from our trying to cling to things, to hold on so tightly to that which, as we already know, is essentially open. In this clinging we crush the joy and the beauty of what is. However we don't have to do this. Instead we can follow the path of wisdom, of harmonious relationship, and of attention.
(source: http://lifestylenutritionmanagement.com/loveandmarriage.htm)